Brain metastases in endometrial cancer: A systematic review of the surgical prognostic factors

Context Although endometrial cancer is the fourth most common malignancy in women, dissemination to brain an exceptional event course of disease. The aim this review determine important surgical prognostic factors for patients with metastatic brain. Materials and methods Report two cases. Medline database was used conduct a systematic literature from inception December 2020 looking English-language articles focused on metastases cancer. Results research yielded 108 articles, among which 23 were retained total 87 patients. Mean age 60 years-old ±11 at time diagnosis cancer, tumors aggressive (grade 3) advanced-stage disease (FIGO III-IV). At cerebral disease, single metastasis (p < 0.0001) no extra-cerebral site = 0.0011) significant good median overall survival. Surgical excision followed by radiotherapy provided longest survival compared and/or chemotherapy, surgery alone (respectively 32, 5.4 4.8 months, p 0.0001). An 60-year-old or less not associated better prognosis. Conclusion This confirms that reliable option site. work could help adapt Graded Prognostic Assessment